Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α

Mutations in the Cu/Zn Superoxide Dismutase (SOD1) gene cause an inherited form of ALS with upper and lower motor neuron loss. The mechanism underlying mutant SOD1-mediated motor neuron degeneration remains unclear. While defects in mitochondrial dynamics contribute to neurodegeneration, including A...

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Bibliographic Details
Main Authors: Wenjun Song, Yuting Song, Brad Kincaid, Blaise Bossy, Ella Bossy-Wetzel
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neurobiology of Disease
Subjects:
Mitochondrial dynamics
Axonal trafficking
Dominant-negative DRP1
Real-time imaging
Astrocyte
Motor neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002458

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http://www.sciencedirect.com/science/article/pii/S0969996112002458

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