Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19

The concept of original antigenic sin (OAS) was put forth many years ago to explain how humoral memory responses generated against one set of antigens can affect the nature of antibody responses elicited to challenge infections or vaccinations containing a similar but not identical array...

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Bibliographic Details
Main Authors: Eric L. Brown, Heather T. Essigmann
Format: Article
Language:English
Published: American Society for Microbiology 2021-04-01
Series:mSphere
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00056-21