MOLECULAR PATHOPHYSIOLOGY AND PHARMACOLOGY OF THE VOLTAGE-SENSING DOMAIN OF NEURONAL ION CHANNELS

MOLECULAR PATHOPHYSIOLOGY AND PHARMACOLOGY OF THE VOLTAGE-SENSING DOMAIN OF NEURONAL ION CHANNELS

Voltage-gated ion channels (VGIC) are membrane proteins that switch from a closed to open state in response to changes in membrane potential, thus enabling ion fluxes across the cell membranes. The mechanism that regulate the structural rearrangements occurring in VGIC in response to changes in memb...

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Bibliographic Details
Main Authors: Francesco eMiceli, Maria Virginia eSoldovieri, Paolo eAmbrosino, Michela eDe Maria, Laura eManocchio, Alessandro eMedoro, Maurizio eTaglialatela
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
mutations
Chanelopathies
Gating modifier
Voltage-sensing domain
io channels
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00259/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00259/full

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