Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer’s Disease

Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer’s Disease

The irreversible and progressive neurodegenerative Alzheimer’s disease (AD) is characterized by cognitive decline, extracellular β-amyloid peptide accumulation, and tau neurofibrillary tangles in the cortex and hippocampus. The triple-transgenic (3xTg) mouse model of AD presents memory impairment in...

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Bibliographic Details
Main Authors: Paola C. Bello-Medina, Fernando Hernández-Quiroz, Marcel Pérez-Morales, Diego A. González-Franco, Guadalupe Cruz-Pauseno, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-López
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Neuroscience
Subjects:
3xTg-AD
dysbiosis
novel-object localization
Actinobacteria
TM7
alpha-diversity
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.595583/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.595583/full

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