Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3.

Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3.

Classical dendritic cells (cDC) are specialized antigen-presenting cells mediating immunity and tolerance. cDC cell-lineage decisions are largely controlled by transcriptional factor regulatory cascades. Using an in vivo cell-specific targeting of Runx3 at various stages of DC lineage development we...

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Bibliographic Details
Main Authors: Joseph Dicken, Alexander Mildner, Dena Leshkowitz, Ivo P Touw, Shay Hantisteanu, Steffen Jung, Yoram Groner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3817345?pdf=render

Internet

http://europepmc.org/articles/PMC3817345?pdf=render

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