A recombinant Chinese measles virus vaccine strain rMV-Hu191 inhibits human colorectal cancer growth through inducing autophagy and apoptosis regulating by PI3K/AKT pathway

A recombinant Chinese measles virus vaccine strain rMV-Hu191 inhibits human colorectal cancer growth through inducing autophagy and apoptosis regulating by PI3K/AKT pathway

The potential therapeutic effects of oncolytic measles virotherapy have been verified against plenty of malignancies. However, the oncolytic effects and underlying mechanisms of the recombinant Chinese measles virus vaccine strain Hu191 (rMV-Hu191) against human colorectal cancer (CRC) remain elusiv...

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Bibliographic Details
Main Authors: Chu-di Zhang, Yi-long Wang, Dong-ming Zhou, Meng-ying Zhu, Yao Lv, Xiao-qiang Hao, Chu-fan Qu, Yi Chen, Wei-zhong Gu, Ben-qing Wu, Pei-chun Chen, Zheng-yan Zhao
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Translational Oncology
Subjects:
Colorectal cancer
Oncolytic measles virotherapy
Apoptosis
Autophagy
PI3K/AKT signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321000838

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http://www.sciencedirect.com/science/article/pii/S1936523321000838

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