Inhibition of integrin αVβ6 changes fibril thickness of stromal collagen in experimental carcinomas

Inhibition of integrin αVβ6 changes fibril thickness of stromal collagen in experimental carcinomas

Abstract Background Chemotherapeutic efficacy can be improved by targeting the structure and function of the extracellular matrix (ECM) in the carcinomal stroma. This can be accomplished by e.g. inhibiting TGF-β1 and -β3 or treating with Imatinib, which results in scarcer collagen fibril structure i...

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Main Authors: P. Olof Olsson, Renata Gustafsson, Alexei V. Salnikov, Maria Göthe, Kathrin S. Zeller, Tomas Friman, Bo Baldetorp, Louise A. Koopman, Paul H. Weinreb, Shelia M. Violette, Sebastian Kalamajski, Nils-Erik Heldin, Kristofer Rubin
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Cell Communication and Signaling
Online Access:http://link.springer.com/article/10.1186/s12964-018-0249-7

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http://link.springer.com/article/10.1186/s12964-018-0249-7

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