H1153Y-<i>KCNH2</i> Mutation Identified in a Sudden Arrhythmic Death Syndrome Case Alters Channel Gating

H1153Y-<i>KCNH2</i> Mutation Identified in a Sudden Arrhythmic Death Syndrome Case Alters Channel Gating

Long QT syndrome is one of the most common hereditary channelopathies inducing fatal arrhythmias and sudden cardiac death. We identified in a sudden arrhythmic death syndrome case a C-term <i>KCNH2</i> mutation (c.3457C > T; p.His1153Tyr) classified as variant of unknown significance...

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Bibliographic Details
Main Authors: Audrey Farrugia, Kevin Rollet, Jérome Sinniger, Susana Brun, Caroline Spenle, Bertrand Ludes, Omar Taleb, Ayikoe Guy Mensah-Nyagan
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
electrophysiology
Kv11.1 channel
long QT syndrome 2
sudden arrhythmic death case
current density
Online Access:https://www.mdpi.com/1422-0067/22/17/9235

Internet

https://www.mdpi.com/1422-0067/22/17/9235

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