Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
The use of tumour exosome-activated dendritic cell (DC) immunotherapy shows promise for the treatment of large established tumours. Here, the authors generate alarmin HMGN1-attached tumour exosomes which significantly improve therapy efficacy by boosting DC activation in several preclinical mouse mo...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-04-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-15569-2 |