α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis

α-Synuclein and Noradrenergic Modulation of Immune Cells in Parkinson’s Disease Pathogenesis

α-synuclein (α-syn) pathology and loss of noradrenergic neurons in the locus coeruleus (LC) are among the most ubiquitous features of Parkinson’s disease (PD). While noradrenergic dysfunction is associated with non-motor symptoms of PD, preclinical research suggests that the loss of LC norepinephrin...

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Bibliographic Details
Main Authors: Laura M. Butkovich, Madelyn C. Houser, Malú G. Tansey
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Neuroscience
Subjects:
α-synuclein
locus coeruleus
Parkinson’s disease
neuroinflammation
norepinephrine
immune cell
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00626/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00626/full

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