Angiogenic inflammation and formation of necrosis in the tumor microenvironment influence patient survival after radical surgery for de novo hepatocellular carcinoma in non-cirrhosis

Angiogenic inflammation and formation of necrosis in the tumor microenvironment influence patient survival after radical surgery for de novo hepatocellular carcinoma in non-cirrhosis

Abstract Background Tumor escape mechanisms mediated in the tumor microenvironment can significantly reduce the capacity of the anti-tumor function of the immune system. TIE2-expressing monocytes (TEMs), related angiopoietins, and tumor necrosis are considered to have a key role in this process. We...

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Bibliographic Details
Main Authors: Georgi Atanasov, Karoline Dino, Katrin Schierle, Corinna Dietel, Gabriela Aust, Johann Pratschke, Daniel Seehofer, Moritz Schmelzle, Hans-Michael Hau
Format: Article
Language:English
Published: BMC 2019-12-01
Series:World Journal of Surgical Oncology
Subjects:
Hepatocellular carcinoma
Tumor-infiltrating macrophages
TIE2-expressing monocytes
Tumor necrosis
Angiopoietins
Angiogenesis
Online Access:https://doi.org/10.1186/s12957-019-1756-8

Internet

https://doi.org/10.1186/s12957-019-1756-8

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