Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements.
The presenilin/gamma-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover. Its ability to liberate numerous intracellular signaling proteins from the membrane and also mediate the secretion of amyloid-beta protein...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-10-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2570425?pdf=render |