Complete protection of mice against lethal murine cytomegalovirus challenge by immunization with DNA vaccines encoding envelope glycoprotein complex III antigens gH, gL and gO.

Complete protection of mice against lethal murine cytomegalovirus challenge by immunization with DNA vaccines encoding envelope glycoprotein complex III antigens gH, gL and gO.

Human cytomegalovirus infects the majority of humanity which may lead to severe morbidity and mortality in newborns and immunocompromised adults. Humoral and cellular immunity are critical for controlling CMV infection. HCMV envelope glycoprotein complexes (gC I, II, III) represent major antigenic t...

Full description

Bibliographic Details
Main Authors: Huadong Wang, Chaoyang Huang, Jinrong Dong, Yanfeng Yao, Zhenyuan Xie, Xueying Liu, Wenjie Zhang, Fang Fang, Ze Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4372543?pdf=render

Internet

http://europepmc.org/articles/PMC4372543?pdf=render

Similar Items