Design, Synthesis, and Biological Activity of New Triazole and Nitro-Triazole Derivatives as Antifungal Agents

Design, Synthesis, and Biological Activity of New Triazole and Nitro-Triazole Derivatives as Antifungal Agents

In this study two series of fluconazole derivatives bearing nitrotriazole (series A) or piperazine ethanol (series B) side chain were designed and synthesized and then docked in the active site of lanosterol 14α-demethylase enzyme (1EA1) using the Autodock 4.2 program (The scripps research institute...

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Bibliographic Details
Main Authors: Hossein Sadeghpour, Soghra Khabnadideh, Kamiar Zomorodian, Keyvan Pakshir, Khadijeh Hoseinpour, Nabiollah Javid, Ehsan Faghih-Mirzaei, Zahra Rezaei
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
fluconazole
synthesis
antifungal
lanosterol 14α-demethylase
docking
nitrotriazole
Online Access:https://www.mdpi.com/1420-3049/22/7/1150

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https://www.mdpi.com/1420-3049/22/7/1150

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