In house colorimetric reverse hybridisation assay for detection of the mutation most frequently associated with resistance to isoniazid in Mycobacterium tuberculosis

In house colorimetric reverse hybridisation assay for detection of the mutation most frequently associated with resistance to isoniazid in Mycobacterium tuberculosis

Mutations in the katG gene have been identified and correlated with isoniazid (INH) resistance in Mycobacterium tuberculosis isolates. The mutation AGC→ACC (Ser→Thr) at katG315 has been reported to be the most frequent and is associated with transmission and multidrug resistance....

Full description

Bibliographic Details
Main Authors: Mirela Verza, Raquel de Abreu Maschmann, Márcia Susana Nunes Silva, Elis Regina Dalla Costa, Marta Osório Ribeiro, Franciele Rosso, Philip Noel Suffys, Enrico Tortoli, Fiorella Marcelli, Arnaldo Zaha, Maria Lucia Rosa Rossetti
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2009-08-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
drug resistance
isoniazid
katG315
reverse hybridization assay
tuberculosis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000500008

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000500008

Similar Items