Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

Dysfunction of autophagy and disturbed protein homeostasis are linked to the pathogenesis of human neurodegenerative diseases and the modulation of autophagy as the protein clearance process has become one key pharmacological target. Due to the role of sigma-1 receptors (Sig-1R) in learning and memo...

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Bibliographic Details
Main Authors: Maximilian G. Christ, Heike Huesmann, Heike Nagel, Andreas Kern, Christian Behl
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
sigma-1 receptor
autophagy
proteostasis
neurodegeneration
C. elegans
Online Access:http://www.mdpi.com/2073-4409/8/3/211

Internet

http://www.mdpi.com/2073-4409/8/3/211

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