Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death

Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death

Abstract Background Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are being wildly used as target therapy in non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mutation are primary resistant to EGFR-TKIs such as gefitinib. Curcumin ha...

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Bibliographic Details
Main Authors: Ping Chen, Han-Peng Huang, Yi Wang, Jun Jin, Wei-Guo Long, Kan Chen, Xiao-Hui Zhao, Chen-Guo Chen, Jian Li
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Non-small-cell lung cancer
Epidermal growth factor receptor (EGFR)
Tyrosine kinase inhibitor (TKI)
Gefitinib
Curcumin
Resistance
Online Access:http://link.springer.com/article/10.1186/s13046-019-1234-8

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http://link.springer.com/article/10.1186/s13046-019-1234-8

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