DNA Damage and L1 Retrotransposition
Barbara McClintock was the first to suggest that transposons are a source of genome instability and that genotoxic stress assisted in their mobilization. The generation of double-stranded DNA breaks (DSBs) is a severe form of genotoxic stress that threatens the integrity of the genome, activates cel...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2006-01-01
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Series: | Journal of Biomedicine and Biotechnology |
Online Access: | http://dx.doi.org/10.1155/JBB/2006/37285 |