Evidence of batch effects masking treatment effect in GAW20 methylation data
Abstract Using the real data set from GAW20, we examined changes in the distribution of DNA methylation before and after treatment. Paired analysis of differences in both mean and variance had grossly inflated type 1 error, suggesting either a very large number of changes across the entire epigenome...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-09-01
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| Series: | BMC Proceedings |
| Online Access: | http://link.springer.com/article/10.1186/s12919-018-0129-6 |