AXL Receptor Tyrosine Kinase as a Therapeutic Target in Hematological Malignancies: Focus on Multiple Myeloma

AXL Receptor Tyrosine Kinase as a Therapeutic Target in Hematological Malignancies: Focus on Multiple Myeloma

AXL belongs to the TAM (TYRO3, AXL, and MERTK) receptor family, a unique subfamily of the receptor tyrosine kinases. Their common ligand is growth arrest-specific protein 6 (GAS6). The GAS6/TAM signaling pathway regulates many important cell processes and plays an essential role in immunity, hemosta...

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Bibliographic Details
Main Authors: Siyang Yan, Niels Vandewalle, Nathan De Beule, Sylvia Faict, Ken Maes, Elke De Bruyne, Eline Menu, Karin Vanderkerken, Kim De Veirman
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
axl
hematological cancers
selective inhibitors
prognostic value
Online Access:https://www.mdpi.com/2072-6694/11/11/1727

Internet

https://www.mdpi.com/2072-6694/11/11/1727

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