Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling
The generation of excessive amounts of reactive oxygen species (ROS) leads to cellular oxidative stress that underlies a variety of forms of hepatocyte injury and death including that from alcohol. Although ROS can induce cell damage through direct effects on cellular macromolecules, the injurious...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2014-01-01
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Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231714001037 |