Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection

Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection

Abstract Background The function of Toll-like receptor 2 (TLR2) in host defense against pathogens, especially Mycobacterium tuberculosis (Mtb) is poorly understood. To investigate the role of TLR2 during mycobacterial infection, we analyzed the response of tlr2 zebrafish mutant larvae to infection w...

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Bibliographic Details
Main Authors: Wanbin Hu, Shuxin Yang, Yasuhito Shimada, Magnus Münch, Rubén Marín-Juez, Annemarie H. Meijer, Herman P. Spaink
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Genomics
Subjects:
Tuberculosis
Mycobacterium
TLR2
RNAseq
RNA deep sequencing
Transcriptomics
Online Access:http://link.springer.com/article/10.1186/s12864-019-6265-1

Internet

http://link.springer.com/article/10.1186/s12864-019-6265-1

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