Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection
Abstract Background The function of Toll-like receptor 2 (TLR2) in host defense against pathogens, especially Mycobacterium tuberculosis (Mtb) is poorly understood. To investigate the role of TLR2 during mycobacterial infection, we analyzed the response of tlr2 zebrafish mutant larvae to infection w...
Main Authors: | Wanbin Hu, Shuxin Yang, Yasuhito Shimada, Magnus Münch, Rubén Marín-Juez, Annemarie H. Meijer, Herman P. Spaink |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-11-01
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Series: | BMC Genomics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12864-019-6265-1 |
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