Transforming growth factor β inhibits platelet derived growth factor-induced vascular smooth muscle cell proliferation via Akt-independent, Smad-mediated cyclin D1 downregulation.

Transforming growth factor β inhibits platelet derived growth factor-induced vascular smooth muscle cell proliferation via Akt-independent, Smad-mediated cyclin D1 downregulation.

In adult tissue, vascular smooth muscle cells (VSMCs) exist in a differentiated phenotype, which is defined by the expression of contractile proteins and lack of proliferation. After vascular injury, VSMC adopt a synthetic phenotype associated with proliferation, migration and matrix secretion. The...

Full description

Bibliographic Details
Main Authors: Abel Martin-Garrido, Holly C Williams, Minyoung Lee, Bonnie Seidel-Rogol, Xinpei Ci, Jin-Tang Dong, Bernard Lassègue, Alejandra San Martín, Kathy K Griendling
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3827379?pdf=render

Internet

http://europepmc.org/articles/PMC3827379?pdf=render

Similar Items