Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation

Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation

DNA methyltransferases (DNMTs) play a relevant role in epigenetic control of cancer cell survival and proliferation. Since only two DNMT inhibitors (azacitidine and decitabine) have been approved to date for the treatment of hematological malignancies, the development of novel potent and specific in...

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Bibliographic Details
Main Authors: Clemens Zwergel, Rossella Fioravanti, Giulia Stazi, Federica Sarno, Cecilia Battistelli, Annalisa Romanelli, Angela Nebbioso, Eduarda Mendes, Alexandra Paulo, Raffaele Strippoli, Marco Tripodi, Dany Pechalrieu, Paola B. Arimondo, Teresa De Luca, Donatella Del Bufalo, Daniela Trisciuoglio, Lucia Altucci, Sergio Valente, Antonello Mai
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
drug discovery
medicinal chemistry
dna methyltransferase
enzyme inhibition
protein degradation
apoptosis
Online Access:https://www.mdpi.com/2072-6694/12/2/447

Internet

https://www.mdpi.com/2072-6694/12/2/447

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