A mechanistic basis for amplification differences between samples and between genome regions

A mechanistic basis for amplification differences between samples and between genome regions

<p>Abstract</p> <p>Background</p> <p>For many analytical methods the efficiency of DNA amplification varies across the genome and between samples. The most affected genome regions tend to correlate with high C + G content, however this relationship is complex and does n...

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Bibliographic Details
Main Authors: Veal Colin D, Freeman Peter J, Jacobs Kevin, Lancaster Owen, Jamain Stéphane, Leboyer Marion, Albanes Demetrius, Vaghela Reshma R, Gut Ivo, Chanock Stephen J, Brookes Anthony J
Format: Article
Language:English
Published: BMC 2012-09-01
Series:BMC Genomics
Subjects:
DNA amplification
DNA denaturation
C + G
Illumina infinium
Online Access:http://www.biomedcentral.com/1471-2164/13/455

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http://www.biomedcentral.com/1471-2164/13/455

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