NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A–T phosphoramidite building blocks

NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A–T phosphoramidite building blocks

Modifications of the nucleic acid backbone are essential for the development of oligonucleotide-derived bioactive agents. The NAA-modification represents a novel artificial internucleotide linkage which enables the site-specific introduction of positive charges into the otherwise polyanionic backbon...

Full description

Bibliographic Details
Main Authors: Boris Schmidtgall, Claudia Höbartner, Christian Ducho
Format: Article
Language:English
Published: Beilstein-Institut 2015-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
backbone modifications
DNA
nucleic acids
oligonucleotides
stereoselective synthesis
zwitterions
Online Access:https://doi.org/10.3762/bjoc.11.8

Internet

https://doi.org/10.3762/bjoc.11.8

Similar Items