In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System

In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System

Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity of drugs in humans. In this study, we examined the...

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Bibliographic Details
Main Authors: Fanny Knöspel, Frank Jacobs, Nora Freyer, Georg Damm, An De Bondt, Ilse van den Wyngaert, Jan Snoeys, Mario Monshouwer, Marco Richter, Nadja Strahl, Daniel Seehofer, Katrin Zeilinger
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:International Journal of Molecular Sciences
Subjects:
primary human hepatocytes, in vitro hepatotoxicity model
three-dimensional (3D) bioreactor
diclofenac
Online Access:http://www.mdpi.com/1422-0067/17/4/584

Internet

http://www.mdpi.com/1422-0067/17/4/584

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