The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory

The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory

The kinesin KIF21B is implicated in several human neurological disorders, including delayed cognitive development, yet it remains unclear how KIF21B dysfunction may contribute to pathology. One limitation is that relatively little is known about KIF21B-mediated physiological functions. Here, we gene...

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Bibliographic Details
Main Authors: Mary Muhia, Edda Thies, Dorthe Labonté, Amy E. Ghiretti, Kira V. Gromova, Francesca Xompero, Corinna Lappe-Siefke, Irm Hermans-Borgmeyer, Dietmar Kuhl, Michaela Schweizer, Ora Ohana, Jürgen R. Schwarz, Erika L.F. Holzbaur, Matthias Kneussel
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Cell Reports
Subjects:
neuron
dendrite
microtubule dynamics
kinesin
KIF21B
LTP
spine
synapse
learning and memory
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716303928

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http://www.sciencedirect.com/science/article/pii/S2211124716303928

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