Affinity of Antifungal Isoxazolo[3,4-<i>b</i>]pyridine-3(1<i>H</i>)-Ones to Phospholipids in Immobilized Artificial Membrane (IAM) Chromatography

Affinity of Antifungal Isoxazolo[3,4-<i>b</i>]pyridine-3(1<i>H</i>)-Ones to Phospholipids in Immobilized Artificial Membrane (IAM) Chromatography

Currently, rapid evaluation of the physicochemical parameters of drug candidates, such as lipophilicity, is in high demand owing to it enabling the approximation of the processes of absorption, distribution, metabolism, and elimination. Although the lipophilicity of drug candidates is determined usi...

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Bibliographic Details
Main Authors: Krzesimir Ciura, Joanna Fedorowicz, Petar Žuvela, Mario Lovrić, Hanna Kapica, Paweł Baranowski, Wiesław Sawicki, Ming Wah Wong, Jarosław Sączewski
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
immobilized artificial membrane
IAM-HPLC
isoxazolo[3,4-<i>b</i>]pyridin-3(1<i>H</i>)-one
isoxazolone
Online Access:https://www.mdpi.com/1420-3049/25/20/4835

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https://www.mdpi.com/1420-3049/25/20/4835

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