Serum exosomes from young rats improve the reduced osteogenic differentiation of BMSCs in aged rats with osteoporosis after fatigue loading in vivo

Serum exosomes from young rats improve the reduced osteogenic differentiation of BMSCs in aged rats with osteoporosis after fatigue loading in vivo

Abstract Background Osteoporosis is a major public health concern for the elderly population and is characterized by fatigue load resulting in bone microdamage. The ability of bone mesenchymal stem cells (BMSCs) to repair bone microdamage diminishes with age, and the accumulation of bone microdamage...

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Bibliographic Details
Main Authors: Jingqiong Xun, Chan Li, Meilu Liu, Yueming Mei, Qiongfei Zhou, Bo Wu, Fen Xie, Yuling Liu, Ruchun Dai
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Stem Cell Research & Therapy
Subjects:
Bone microdamage
Bone mesenchymal stem cells
Exosomes
Ageing
Osteogenic differentiation
Osteoporotic fracture
Online Access:https://doi.org/10.1186/s13287-021-02449-9

Internet

https://doi.org/10.1186/s13287-021-02449-9

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