The human cytomegalovirus UL133-138 gene locus attenuates the lytic viral cycle in fibroblasts.

The genomes of HCMV clinical strains (e.g. FIX, TR, PH, etc) contain a 15 kb region that encodes 20 putative ORFs. The region, termed ULb', is lost after serial passage of virus in human foreskin fibroblast (HFF) cell culture. Compared to clinical strains, laboratory strains replicate faster an...

Full description

Bibliographic Details
Main Authors: Nirmal Dutta, Philip Lashmit, Jinxiang Yuan, Jeffery Meier, Mark F Stinski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370700?pdf=render