HLA Variants and Inhibitor Development in Hemophilia A: A Retrospective Case-Controlled Study Using the ATHNdataset

HLA Variants and Inhibitor Development in Hemophilia A: A Retrospective Case-Controlled Study Using the ATHNdataset

In hemophilia A (HA) patients, F8 gene-defects as genetic risk-factors for developing inhibitors to Factor VIII have been extensively studied. Here we provide estimates of inhibitor-risk associated with the patient's Human Leukocyte Antigen (HLA). We used next generation sequencing for high-res...

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Bibliographic Details
Main Authors: Joseph R. McGill, Vijaya L. Simhadri, Zuben E. Sauna
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Medicine
Subjects:
inhibitors
factor VIII
HLA-type
statistics
hemophilia
ATHN
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.663396/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.663396/full

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