Induction of Redox-Mediated Cell Death in ER-Positive and ER-Negative Breast Cancer Cells by a Copper(II)-Phenolate Complex: An In Vitro and In Silico Study

Induction of Redox-Mediated Cell Death in ER-Positive and ER-Negative Breast Cancer Cells by a Copper(II)-Phenolate Complex: An In Vitro and In Silico Study

This research was aimed at finding the cytotoxic potential of the mixed ligand copper(II) complex [Cu(tdp)(phen)](ClO<sub>4</sub>)—where H(tdp) is the tetradentate ligand 2-[(2-(2-hydroxyethylamino)-ethylimino)methyl]phenol, and phen is 1,10-phenanthroline—to two genotypically different...

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Bibliographic Details
Main Authors: Vaiyapuri Subbarayan Periasamy, Anvarbatcha Riyasdeen, Venugopal Rajendiran, Mallayan Palaniandavar, Hanumanthappa Krishnamurthy, Ali Abdullah Alshatwi, Mohammad Abdulkader Akbarsha
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
anticancer agents
apoptosis
breast cancer
cell cycle arrest
copper(II)-phenolate complex
necrosis
Online Access:https://www.mdpi.com/1420-3049/25/19/4504

Internet

https://www.mdpi.com/1420-3049/25/19/4504

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