Dihomo-γ-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase

Dihomo-γ-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase

Abstract Background We previously demonstrated that knockdown of delta-5-desaturase via siRNA transfection together with dihomo-γ-linolenic acid supplementation inhibited colon cancer cell growth and migration, by promoting the production of the anti-cancer byproduct 8-hydroxyoctanoic acid from Cycl...

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Bibliographic Details
Main Authors: Yi Xu, Xiaoyu Yang, Di Gao, Liu Yang, Keith Miskimins, Steven Y. Qian
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cancer
Subjects:
COX-2-catalyzed DGLA peroxidation
Knockdown of delta-5-desaturase
Xenograft tumor
Cancer growth and migration
HDAC inhibitor
Online Access:http://link.springer.com/article/10.1186/s12885-018-5185-9

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http://link.springer.com/article/10.1186/s12885-018-5185-9

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