Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

Abstract Cytosolic double‐stranded DNA (dsDNA) is a danger signal that is tightly monitored and sensed by nucleic acid‐sensing pattern recognition receptors. We study the inflammatory cascade on dsDNA recognition and investigate the neuroprotective effect of cyclic GMP‐AMP (cGAMP) synthase (cGAS) an...

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Bibliographic Details
Main Authors: Qian Li, Yuze Cao, Chun Dang, Bin Han, Ranran Han, Heping Ma, Junwei Hao, Lihua Wang
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:EMBO Molecular Medicine
Subjects:
cGAS
microglia
neuroinflammation
pyroptosis
stroke
Online Access:https://doi.org/10.15252/emmm.201911002

Internet

https://doi.org/10.15252/emmm.201911002

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