Atrial Fibrillation Progression Is Associated with Cell Senescence Burden as Determined by p53 and p16 Expression

Atrial Fibrillation Progression Is Associated with Cell Senescence Burden as Determined by p53 and p16 Expression

Background: Whilst the link between aging and thrombogenicity in atrial fibrillation (AF) is well established, the cellular underlying mechanisms are unknown. In AF, the role of senescence in tissue remodeling and prothrombotic state remains unclear. Aims: We investigated the link between AF and sen...

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Bibliographic Details
Main Authors: Laurence Jesel, Malak Abbas, Sin-Hee Park, Kensuke Matsushita, Michel Kindo, Hira Hasan, Cyril Auger, Chisato Sato, Patrick Ohlmann, Jean-Philippe Mazzucotelli, Florence Toti, Gilles Kauffenstein, Valérie Schini-Kerth, Olivier Morel
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Journal of Clinical Medicine
Subjects:
atrial fibrillation
senescence
aging
tissue factor
endothelial dysfunction
remodeling
Online Access:https://www.mdpi.com/2077-0383/9/1/36

Internet

https://www.mdpi.com/2077-0383/9/1/36

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