Atrial Fibrillation Progression Is Associated with Cell Senescence Burden as Determined by p53 and p16 Expression
Background: Whilst the link between aging and thrombogenicity in atrial fibrillation (AF) is well established, the cellular underlying mechanisms are unknown. In AF, the role of senescence in tissue remodeling and prothrombotic state remains unclear. Aims: We investigated the link between AF and sen...
Main Authors: | Laurence Jesel, Malak Abbas, Sin-Hee Park, Kensuke Matsushita, Michel Kindo, Hira Hasan, Cyril Auger, Chisato Sato, Patrick Ohlmann, Jean-Philippe Mazzucotelli, Florence Toti, Gilles Kauffenstein, Valérie Schini-Kerth, Olivier Morel |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-12-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/9/1/36 |
Similar Items
-
Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns
by: Hira Hasan, et al.
Published: (2019-10-01) -
Angiotensin II-induced upregulation of SGLT1 and 2 contributes to human microparticle‐stimulated endothelial senescence and dysfunction: protective effect of gliflozins
by: Sin-Hee Park, et al.
Published: (2021-03-01) -
Sénescence, remodelage tissulaire et membranaire, risque thrombotique au cours de la fibrillation auriculaire
by: Jesel-Morel, Laurence
Published: (2016) -
Epigenetic Landmarks of Leaf Senescence and Crop Improvement
by: Agnieszka Ostrowska-Mazurek, et al.
Published: (2020-07-01) -
TNFRSF12A and CD38 Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways
by: Yan Dong, et al.
Published: (2020-05-01)