Antioxidant or pro-oxidant and glutathione transferase P1-1 inhibiting activities for Tamarindus indica seeds and their cytotoxic effect on MCF-7 cancer cell line

Antioxidant or pro-oxidant and glutathione transferase P1-1 inhibiting activities for Tamarindus indica seeds and their cytotoxic effect on MCF-7 cancer cell line

Abstract Background The multidrug resistance (MDR) of cancer cells is a major obstacle to cancer treatment. Glutathione S-transferase Pi (GSTP1-1) catalyzes the conjugation of glutathione with anticancer drugs and therefore reduces their efficacy. Phenolic compounds have the potential to inhibit GST...

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Bibliographic Details
Main Authors: R. A. Guneidy, A. M. Gad, E. R. Zaki, F. M. Ibrahim, A. Shokeer
Format: Article
Language:English
Published: SpringerOpen 2020-11-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Cancer
Glutathione transferase
Phenolic compounds
Antioxidant/pro-oxidant balance
Anticancer drugs
Herb-drug interaction
Online Access:http://link.springer.com/article/10.1186/s43141-020-00077-z

Internet

http://link.springer.com/article/10.1186/s43141-020-00077-z

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