Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

Abstract Background Skeletal muscle atrophy is a common feature of numerous chronic pathologies and is correlated with patient mortality. The REDD1 protein is currently recognized as a negative regulator of muscle mass through inhibition of the Akt/mTORC1 signaling pathway. REDD1 expression is notab...

Full description

Bibliographic Details
Main Authors: Florian A. Britto, Fabienne Cortade, Yassine Belloum, Marine Blaquière, Yann S. Gallot, Aurélie Docquier, Allan F. Pagano, Elodie Jublanc, Nadia Bendridi, Christelle Koechlin-Ramonatxo, Béatrice Chabi, Marc Francaux, François Casas, Damien Freyssenet, Jennifer Rieusset, Sophie Giorgetti-Peraldi, Gilles Carnac, Vincent Ollendorff, François B. Favier
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Biology
Subjects:
Skeletal muscle
Metabolism
Hypoxia
Fasting
Exercise
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s12915-018-0525-4

Internet

http://link.springer.com/article/10.1186/s12915-018-0525-4

Similar Items