Human CD3+ T-Cells with the Anti-ERBB2 Chimeric Antigen Receptor Exhibit Efficient Targeting and Induce Apoptosis in ERBB2 Overexpressing Breast Cancer Cells

Human CD3+ T-Cells with the Anti-ERBB2 Chimeric Antigen Receptor Exhibit Efficient Targeting and Induce Apoptosis in ERBB2 Overexpressing Breast Cancer Cells

Breast cancer is a common malignancy among women. The innate and adaptive immune responses failed to be activated owing to immune modulation in the tumour microenvironment. Decades of scientific study links the overexpression of human epidermal growth factor receptor 2 (ERBB2) antigen with aggressiv...

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Bibliographic Details
Main Authors: Rusheni Munisvaradass, Suresh Kumar, Chandramohan Govindasamy, Khalid S. Alnumair, Pooi Ling Mok
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
chimeric antigen receptor (CAR)
human epidermal growth factor receptor (ERBB2)
immunotherapy
transduction
human T-cells
Online Access:https://www.mdpi.com/1422-0067/18/9/1797

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https://www.mdpi.com/1422-0067/18/9/1797

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