High Serine-arginine Protein Kinase 1 Expression with PTEN Loss Defines Aggressive Phenotype of Prostate Cancer Associated with Lethal Outcome and Decreased Overall Survival

High Serine-arginine Protein Kinase 1 Expression with PTEN Loss Defines Aggressive Phenotype of Prostate Cancer Associated with Lethal Outcome and Decreased Overall Survival

Background: Serine-arginine protein kinase 1 (SRPK1) has been implicated in prostate cancer (PCa) progression. However, its prognostic value and association with ERG and PTEN expression, two of the most common genetic alterations, have not been explored fully. Objective: We assessed the prognostic v...

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Bibliographic Details
Main Authors: Hatem Abou-Ouf, Hisham Assem, Sunita Ghosh, R. Jeffrey Karnes, Konstantin Stoletov, Nallasivam Palanisamy, John D. Lewis, Tarek A. Bismar
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:European Urology Open Science
Subjects:
SRPK1
PTEN
ERG
Protein expression
Immunohistochemistry
Gleason score
Online Access:http://www.sciencedirect.com/science/article/pii/S2666168320363680

Internet

http://www.sciencedirect.com/science/article/pii/S2666168320363680

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