Immunization of Rabbits with Recombinant Human Cytomegalovirus Trimeric versus Monomeric gH/gL Protein Elicits Markedly Higher Titers of Antibody and Neutralization Activity

Immunization of Rabbits with Recombinant Human Cytomegalovirus Trimeric versus Monomeric gH/gL Protein Elicits Markedly Higher Titers of Antibody and Neutralization Activity

Congenital human cytomegalovirus (HCMV) infection and HCMV infection of immunosuppressed patients cause significant morbidity and mortality, and vaccine development against HCMV is a major public health priority. HCMV envelope glycoproteins gB, gH, and gL, which constitute the core fusion machinery,...

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Bibliographic Details
Main Authors: Xinle Cui, Zhouhong Cao, Shuishu Wang, Michael Flora, Stuart P. Adler, Michael A. McVoy, Clifford M. Snapper
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
human cytomegalovirus (HCMV)
vaccine
HCMV gB
HCMV gH/gL
core fusion machinery
neutralizing antibody
congenital infection
solid organ transplantation
hematopoietic stem cell transplantation
Online Access:https://www.mdpi.com/1422-0067/20/13/3158

Internet

https://www.mdpi.com/1422-0067/20/13/3158

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