Dysregulation of the mesoprefrontal dopamine circuit mediates an early-life stress-induced synaptic imbalance in the prefrontal cortex

Dysregulation of the mesoprefrontal dopamine circuit mediates an early-life stress-induced synaptic imbalance in the prefrontal cortex

Summary: Stress adversely affects an array of cognitive functions. Although stress-related disorders are often addressed in adulthood, far less is known about how early-life stress (ELS) affects the developing brain in early postnatal periods. Here we show that ELS, induced by maternal separation, l...

Full description

Bibliographic Details
Main Authors: Won Chan Oh, Gabriela Rodríguez, Douglas Asede, Kanghoon Jung, In-Wook Hwang, Roberto Ogelman, McLean M. Bolton, Hyung-Bae Kwon
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
early-life stress
dopamine
excitatory synapse
inhibitory synapse
PFC
VTA
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004058

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721004058

Similar Items