Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage

Widespread overexpression from the four DNA hypermethylated HOX clusters in aggressive (IDHwt) glioma is associated with H3K27me3 depletion and alternative promoter usage

In human, the 39 coding HOX genes and 18 referenced noncoding antisense transcripts are arranged in four genomic clusters named HOXA, B, C, and D. This highly conserved family belongs to the homeobox class of genes that encode transcription factors required for normal development. Therefore, HOX gen...

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Bibliographic Details
Main Authors: Elisa Le Boiteux, Franck Court, Pierre‐Olivier Guichet, Catherine Vaurs‐Barrière, Isabelle Vaillant, Emmanuel Chautard, Pierre Verrelle, Bruno M. Costa, Lucie Karayan‐Tapon, Anne Fogli, Philippe Arnaud
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Molecular Oncology
Subjects:
alternative promoters
cancer
epigenetics
glioma
glioma stem cells
HOX genes
Online Access:https://doi.org/10.1002/1878-0261.12944

Internet

https://doi.org/10.1002/1878-0261.12944

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