Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer

Abstract Estrogen signaling is crucial for breast cancer initiation and progression. Endocrine-based therapies comprising estrogen receptor (ER) modulators and aromatase inhibitors remain the mainstay of treatment. This study aimed at investigating the antitumor potential of the most potent compound...

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Bibliographic Details
Main Authors: Dina M. El-Kersh, Shahira M. Ezzat, Maha M. Salama, Engy A. Mahrous, Yasmeen M. Attia, Mahmoud Salama Ahmed, Mohey M. Elmazar
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86599-z