MET inhibition downregulates DR4 expression in MET-amplified lung cancer cells with acquired resistance to EGFR inhibitors through suppressing AP-1-mediated transcription

MET inhibition downregulates DR4 expression in MET-amplified lung cancer cells with acquired resistance to EGFR inhibitors through suppressing AP-1-mediated transcription

Death receptor 4 (DR4) is a cell surface protein that is generally thought to mediate apoptosis upon binding to its ligand named TRAIL. However, its contribution to apoptosis resistance has also been reported. MET (or c-MET) gene amplification represents an important mechanism for acquired resistanc...

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Bibliographic Details
Main Authors: Liang Deng, Karin A. Vallega, Shuo Zhang, Puyu Shi, Shi-Yong Sun
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
MET
DR4
EGFR-TKIs
Acquired resistance
Lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000476

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http://www.sciencedirect.com/science/article/pii/S1476558621000476

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