Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation

Restoration of type I interferon signaling in intrahepatically primed CD8+ T cells promotes functional differentiation

Hepatitis B virus–specific (HBV-specific) CD8+ T cells fail to acquire effector functions after priming in the liver, but the molecular basis for the dysfunction is poorly understood. By comparing the gene expression profile of intrahepatically primed, dysfunctional HBV-specific CD8+ T cells with th...

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Bibliographic Details
Main Authors: Keigo Kawashima, Masanori Isogawa, Masaya Onishi, Ian Baudi, Satoru Saito, Atsushi Nakajima, Takashi Fujita, Yasuhito Tanaka
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-02-01
Series:JCI Insight
Subjects:
Immunology
Infectious disease
Online Access:https://doi.org/10.1172/jci.insight.145761

Internet

https://doi.org/10.1172/jci.insight.145761

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