Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays

Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays

The nuclear receptor, estrogen-related receptor alpha (ERRα; NR3B1), plays a pivotal role in energy homeostasis. Its expression fluctuates with the demands of energy production in various tissues. When paired with the peroxisome proliferator-activated receptor γ coactivator 1&#...

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Bibliographic Details
Main Authors: Caitlin Lynch, Jinghua Zhao, Srilatha Sakamuru, Li Zhang, Ruili Huang, Kristine L. Witt, B. Alex Merrick, Christina T. Teng, Menghang Xia
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
ERRα
endocrine disruption
bioenergetic signaling pathways
mechanism of action
cancer
Online Access:https://www.mdpi.com/1420-3049/24/5/841

Internet

https://www.mdpi.com/1420-3049/24/5/841

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