Asymmetric Cryo-EM Structure of Anthrax Toxin Protective Antigen Pore with Lethal Factor N-Terminal Domain

Asymmetric Cryo-EM Structure of Anthrax Toxin Protective Antigen Pore with Lethal Factor N-Terminal Domain

The anthrax lethal toxin consists of protective antigen (PA) and lethal factor (LF). Understanding both the PA pore formation and LF translocation through the PA pore is crucial to mitigating and perhaps preventing anthrax disease. To better understand the interactions of the LF-PA engagement comple...

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Bibliographic Details
Main Authors: Alexandra J. Machen, Narahari Akkaladevi, Caleb Trecazzi, Pierce T. O’Neil, Srayanta Mukherjee, Yifei Qi, Rebecca Dillard, Wonpil Im, Edward P. Gogol, Tommi A. White, Mark T. Fisher
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Toxins
Subjects:
anthrax toxin
lethal factor
protective antigen
pore formation
translocation
nanodisc
cryo-EM
cryoSPARC
Online Access:https://www.mdpi.com/2072-6651/9/10/298

Internet

https://www.mdpi.com/2072-6651/9/10/298

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